Version 5.4
Homo sapiens Protein: HTR3C
Summary
InnateDB Protein IDBP-67335.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTR3C
Protein Name 5-hydroxytryptamine (serotonin) receptor 3, family member C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000322617
InnateDB Gene IDBG-67333 (HTR3C)
Protein Structure
UniProt Annotation
Function This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Subcellular Localization Cell membrane {ECO:0000269PubMed:17392525}; Multi-pass membrane protein {ECO:0000269PubMed:17392525}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
Disease Associations
Tissue Specificity Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney. {ECO:0000269PubMed:12801637}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005230 extracellular ligand-gated ion channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
PFAM PF02932
PF02931
PRINTS PR00252
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WXA8
PhosphoSite PhosphoSite-Q8WXA8
TrEMBL
UniProt Splice Variant
Entrez Gene 170572
UniGene Hs.632579
RefSeq NP_570126
HUGO HGNC:24003
OMIM 610121
CCDS CCDS3250
HPRD 17120
IMGT
EMBL AF459285 BC131799 CH471052
GenPept AAI31800 AAL66182 EAW78305

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca