Version 5.4
| Homo sapiens Protein: HTR3E | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||
| InnateDB Protein | IDBP-67357.7 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | HTR3E | ||||||||
| Protein Name | 5-hydroxytryptamine (serotonin) receptor 3, family member E | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000335511 | ||||||||
| InnateDB Gene | IDBG-67355 (HTR3E) | ||||||||
| Protein Structure |
|
||||||||
| UniProt Annotation | |||||||||
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000269PubMed:17392525, ECO:0000269PubMed:19012743}; Multi-pass membrane protein {ECO:0000269PubMed:17392525, ECO:0000269PubMed:19012743}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in adult colon and intestine. {ECO:0000269PubMed:12801637, ECO:0000269PubMed:14597179}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
||||||||
| Gene Ontology | |||||||||
Molecular Function |
|
||||||||
| Biological Process |
|
||||||||
| Cellular Component |
|
||||||||
| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR006029
Neurotransmitter-gated ion-channel transmembrane domain IPR006201 Neurotransmitter-gated ion-channel IPR006202 Neurotransmitter-gated ion-channel ligand-binding |
||||||||
| PFAM |
PF02932
PF02931 |
||||||||
| PRINTS |
PR00252
|
||||||||
| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | A5X5Y0 | ||||||||
| PhosphoSite | PhosphoSite-A5X5Y0 | ||||||||
| TrEMBL | C9J420 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 285242 | ||||||||
| UniGene | Hs.449179 | ||||||||
| RefSeq | NP_872395 | ||||||||
| HUGO | HGNC:24005 | ||||||||
| OMIM | 610123 | ||||||||
| CCDS | CCDS3251 | ||||||||
| HPRD | 17122 | ||||||||
| IMGT | |||||||||
| EMBL | AC131235 AY159813 AY349352 AY349353 BC101182 BC101183 BC101185 DQ644022 EU165354 | ||||||||
| GenPept | AAI01183 AAI01184 AAI01186 AAO38167 AAQ93476 AAQ93477 ABG35128 ABW05298 | ||||||||