InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACTR3

Summary

InnateDB Protein

IDBP-67371.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTR3

Protein Name

ARP3 actin-related protein 3 homolog (yeast)

Synonyms

ARP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000263238

InnateDB Gene

IDBG-67369 (ACTR3)

Protein Structure

UniProt Annotation

Function

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. {ECO:0000269PubMed:20393563, ECO:0000269PubMed:9000076}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell projection. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	68 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0006928	cellular component movement
GO:0007163	establishment or maintenance of cell polarity
GO:0008356	asymmetric cell division
GO:0009743	response to carbohydrate
GO:0010592	positive regulation of lamellipodium assembly
GO:0016344	meiotic chromosome movement towards spindle pole
GO:0030838	positive regulation of actin filament polymerization
GO:0033206	cytokinesis after meiosis
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043519	regulation of myosin II filament organization
GO:0045087	innate immune response
GO:0045666	positive regulation of neuron differentiation
GO:0046677	response to antibiotic
GO:0050775	positive regulation of dendrite morphogenesis
GO:0051321	meiotic cell cycle
GO:0051491	positive regulation of filopodium assembly
GO:0051653	spindle localization
GO:0060271	cilium morphogenesis

Cellular Component

GO:0000139	Golgi membrane
GO:0002102	podosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005885	Arp2/3 protein complex
GO:0005911	cell-cell junction
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030056	hemidesmosome
GO:0031252	cell leading edge
GO:0060076	excitatory synapse
GO:0070062	extracellular vesicular exosome