InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DVL3

Summary

InnateDB Protein

IDBP-67449.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DVL3

Protein Name

dishevelled, dsh homolog 3 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000316054

InnateDB Gene

IDBG-67447 (DVL3)

Protein Structure

UniProt Annotation

Function

May play a role in the signal transduction pathway mediated by multiple Wnt genes.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	60 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004871	signal transducer activity
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0003007	heart morphogenesis
GO:0003148	outflow tract septum morphogenesis
GO:0016055	Wnt signaling pathway
GO:0035556	intracellular signal transduction
GO:0035567	non-canonical Wnt signaling pathway
GO:0038031	non-canonical Wnt signaling pathway via JNK cascade
GO:0042493	response to drug
GO:0043507	positive regulation of JUN kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060026	convergent extension
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0090103	cochlea morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure

Cellular Component

GO:0005737	cytoplasm
GO:0005938	cell cortex

Protein Structure and Domains

PDB ID

InterPro

IPR000591 DEP domain
IPR001158 DIX domain
IPR001478 PDZ domain
IPR003351 Dishevelled protein domain
IPR008339 Dishevelled family
IPR008342 Dishevelled-3
IPR024580 Dishevelled C-terminal

PFAM

PF00610
PF00778
PF00595
PF13180
PF02377
PF12316

PRINTS

PR01760
PR01763

PIRSF

SMART

SM00049
SM00021
SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt