InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSPT2

Summary

InnateDB Protein

IDBP-67489.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSPT2

Protein Name

G1 to S phase transition 2

Synonyms

ERF3B; GST2;

Species

Homo sapiens

Ensembl Protein

ENSP00000341247

InnateDB Gene

IDBG-67485 (GSPT2)

Protein Structure

UniProt Annotation

Function

Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. {ECO:0000269PubMed:11524954, ECO:0000269PubMed:15987998, ECO:0000269PubMed:17562865}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in IUCC stage II colorectal cancer (CRC). {ECO:0000269PubMed:16721809}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006184	GTP catabolic process
GO:0006412	translation
GO:0006415	translational termination
GO:0007049	cell cycle
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR009000 Translation protein, beta-barrel domain
IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
IPR009818 Ataxin-2, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF03143
PF03144
PF07145

PRINTS

PR00315

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IYD1