Version 5.4
Homo sapiens Gene: GSPT2
Summary
InnateDB Gene IDBG-67485.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSPT2
Gene Name G1 to S phase transition 2
Synonyms ERF3B; GST2
Species Homo sapiens
Ensembl Gene ENSG00000189369
Encoded Proteins
IDBP-67489
G1 to S phase transition 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:51743431-51746232
Strand Forward strand
Band p11.22
Transcripts
ENST00000340438 ENSP00000341247
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006184 GTP catabolic process
GO:0006412 translation
GO:0006415 translational termination
GO:0007049 cell cycle
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000071723
View Gene Order
Pathways
NETPATH
REACTOME
REACT_75768
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_1986
Eukaryotic Translation Termination pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_71
Gene Expression pathway
KEGG
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q8IYD1
TrEMBL
UniProt Splice Variant
Entrez Gene 23708
UniGene Hs.59523
RefSeq NM_018094
HUGO HGNC:4622
OMIM 300418
CCDS CCDS14336
HPRD 02334
IMGT
EMBL AJ251548 AK001303 AL929101 BC036077 CH471230
GenPept AAH36077 BAA91612 CAB91089 CAH71524 EAW62898
RNA Seq Atlas 23708

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca