InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAGED1

Summary

InnateDB Protein

IDBP-67554.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAGED1

Protein Name

melanoma antigen family D, 1

Synonyms

DLXIN-1; NRAGE;

Species

Homo sapiens

Ensembl Protein

ENSP00000364874

InnateDB Gene

IDBG-67550 (MAGED1)

Protein Structure

UniProt Annotation

Function

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269PubMed:20864041}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	82 [view]
Protein-Protein	82 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0032922	circadian regulation of gene expression
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050680	negative regulation of epithelial cell proliferation
GO:0097190	apoptotic signaling pathway