InnateDB Protein
|
IDBP-67556.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MAGED1
|
Protein Name
|
melanoma antigen family D, 1
|
Synonyms
|
DLXIN-1; NRAGE;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000325333
|
InnateDB Gene
|
IDBG-67550 (MAGED1)
|
Protein Structure
|
|
Function |
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269PubMed:20864041}.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
82
[view]
|
Protein-Protein |
82
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
12 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR002190
MAGE protein
|
PFAM |
PF01454
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9Y5V3
|
PhosphoSite |
PhosphoSite-Q9Y5V3
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
9500
|
UniGene |
Hs.5258
|
RefSeq |
NP_008917
|
HUGO |
HGNC:6813
|
OMIM |
300224
|
CCDS |
CCDS14337
|
HPRD |
02202
|
IMGT |
|
EMBL |
AF124440
AF132205
AF217963
AF258554
AF300328
AL133628
AL929410
BC014070
BC032473
|
GenPept |
AAD31421
AAG09704
AAG23757
AAG35551
AAH14070
AAH32473
AAQ14483
CAB63752
CAH71560
CAH71561
|
|
|