InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FDXR

Summary

InnateDB Protein

IDBP-67704.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FDXR

Protein Name

ferredoxin reductase

Synonyms

ADXR;

Species

Homo sapiens

Ensembl Protein

ENSP00000293195

InnateDB Gene

IDBG-67702 (FDXR)

Protein Structure

UniProt Annotation

Function

Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004324	ferredoxin-NADP+ reductase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006694	steroid biosynthetic process
GO:0008203	cholesterol metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process