Version 5.4
Homo sapiens Gene: FDXR
Summary
InnateDB Gene IDBG-67702.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FDXR
Gene Name ferredoxin reductase
Synonyms ADXR
Species Homo sapiens
Ensembl Gene ENSG00000161513
Encoded Proteins
IDBP-67704
ferredoxin reductase
IDBP-384209
ferredoxin reductase
IDBP-384211
ferredoxin reductase
IDBP-384213
ferredoxin reductase
IDBP-593007
ferredoxin reductase
IDBP-763558
IDBP-762942
IDBP-764551
IDBP-760138
IDBP-762035
IDBP-762716
IDBP-763544
IDBP-763461
IDBP-760208
IDBP-762513
IDBP-759917
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:74862497-74873031
Strand Reverse strand
Band q25.1
Transcripts
ENST00000293195 ENSP00000293195
ENST00000442102 ENSP00000416515
ENST00000413947 ENSP00000408595
ENST00000420580 ENSP00000414172
ENST00000544854 ENSP00000445432
ENST00000579482 ENSP00000461993
ENST00000577509 ENSP00000462083
ENST00000582710 ENSP00000462884
ENST00000579893 ENSP00000463308
ENST00000583917 ENSP00000463940
ENST00000578473
ENST00000581219 ENSP00000463934
ENST00000580492 ENSP00000462330
ENST00000579543 ENSP00000462488
ENST00000581969
ENST00000577932
ENST00000583881 ENSP00000464670
ENST00000582944 ENSP00000462183
ENST00000581530 ENSP00000462972
ENST00000610946
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004324 ferredoxin-NADP+ reductase activity
GO:0005515 protein binding
GO:0015039 NADPH-adrenodoxin reductase activity
GO:0016491 oxidoreductase activity
GO:0070402 NADPH binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006694 steroid biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0070995 NADPH oxidation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018861
View Gene Order
ENSBTAG00000006525
Not yet available
Pathways
NETPATH
REACTOME
REACT_11038
Pregnenolone biosynthesis pathway
REACT_150128
Electron transport from NADPH to Ferredoxin pathway
REACT_150353
Mitochondrial iron-sulfur cluster biogenesis pathway
REACT_13812
Endogenous sterols pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 2232
UniGene Hs.69745
RefSeq NM_001258012 NM_001258013 NM_001258014 NM_001258015 NM_001258016 NM_004110 NM_024417 XM_006721772 XM_006721773
HUGO HGNC:3642
OMIM 103270
CCDS CCDS11707 CCDS58591 CCDS58592 CCDS58593 CCDS58594 CCDS58595 CCDS58596
HPRD 00060
IMGT
EMBL
GenPept
RNA Seq Atlas 2232

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca