Version 5.4
Homo sapiens Protein: MTNR1B
Summary
InnateDB Protein IDBP-67846.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTNR1B
Protein Name melatonin receptor 1B
Synonyms FGQTL2; MEL-1B-R; MT2;
Species Homo sapiens
Ensembl Protein ENSP00000257068
InnateDB Gene IDBG-67844 (MTNR1B)
Protein Structure
UniProt Annotation
Function High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in retina and less in brain and hippocampus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0008502 melatonin receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268 synaptic transmission
GO:0042593 glucose homeostasis
GO:0050796 regulation of insulin secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000025 Melatonin receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR002278 Melatonin receptor 1A
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
PFAM PF00001
PF10320
PF10328
PRINTS PR00857
PR00237
PR01012
PR01149
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49286
PhosphoSite PhosphoSite-
TrEMBL Q8TEV7
UniProt Splice Variant
Entrez Gene 4544
UniGene Hs.569039
RefSeq NP_005950
HUGO HGNC:7464
OMIM 600804
CCDS CCDS8290
HPRD 02882
IMGT
EMBL AB033598 AF467654 AY521019 BC069163 U25341
GenPept AAC50612 AAH69163 AAL75503 AAS00461 BAA92315

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca