Version 5.4
Homo sapiens Gene: MTNR1B
Summary
InnateDB Gene IDBG-67844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTNR1B
Gene Name melatonin receptor 1B
Synonyms FGQTL2; MEL-1B-R; MT2
Species Homo sapiens
Ensembl Gene ENSG00000134640
Encoded Proteins
IDBP-67846
melatonin receptor 1B
IDBP-583831
melatonin receptor 1B
IDBP-601000
melatonin receptor 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:92969720-92985066
Strand Forward strand
Band q14.3
Transcripts
ENST00000257068 ENSP00000257068
ENST00000532482 ENSP00000436101
ENST00000528076 ENSP00000433573
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0008502 melatonin receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268 synaptic transmission
GO:0042593 glucose homeostasis
GO:0050796 regulation of insulin secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000050901
View Gene Order
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 4544
UniGene Hs.569039
RefSeq NM_005959
HUGO HGNC:7464
OMIM 600804
CCDS CCDS8290
HPRD 02882
IMGT
EMBL
GenPept
RNA Seq Atlas 4544

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca