InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DOCK2

Summary

InnateDB Protein

IDBP-679759.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOCK2

Protein Name

dedicator of cytokinesis 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019460

InnateDB Gene

IDBG-628386 (DOCK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0020037	heme binding
GO:0030675	Rac GTPase activator activity
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0042608	T cell receptor binding

Biological Process

GO:0001766	membrane raft polarization
GO:0001768	establishment of T cell polarity
GO:0001771	immunological synapse formation
GO:0002277	myeloid dendritic cell activation involved in immune response
GO:0006935	chemotaxis
GO:0007010	cytoskeleton organization
GO:0007264	small GTPase mediated signal transduction
GO:0032855	positive regulation of Rac GTPase activity
GO:0042098	T cell proliferation
GO:0042110	T cell activation
GO:0044351	macropinocytosis
GO:0045059	positive thymic T cell selection
GO:0045060	negative thymic T cell selection
GO:0046631	alpha-beta T cell activation
GO:0046633	alpha-beta T cell proliferation
GO:0050766	positive regulation of phagocytosis

Cellular Component

GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR009056 Cytochrome c-like domain
IPR010703 Dedicator of cytokinesis C-terminal
IPR011511 Variant SH3 domain
IPR016024 Armadillo-type fold

PFAM

PF00018
PF14604
PF13442
PF06920
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt