Version 5.4
Bos taurus Gene: DOCK2
Summary
InnateDB Gene IDBG-628386.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOCK2
Gene Name dedicator of cytokinesis 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014612
Encoded Proteins
IDBP-679759
dedicator of cytokinesis 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134516:
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:1452376-1893741
Strand Forward strand
Band
Transcripts
ENSBTAT00000019460 ENSBTAP00000019460
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0020037 heme binding
GO:0030675 Rac GTPase activator activity
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0042608 T cell receptor binding
Biological Process
GO:0001766 membrane raft polarization
GO:0001768 establishment of T cell polarity
GO:0001771 immunological synapse formation
GO:0002277 myeloid dendritic cell activation involved in immune response
GO:0006935 chemotaxis
GO:0007010 cytoskeleton organization
GO:0007264 small GTPase mediated signal transduction
GO:0032855 positive regulation of Rac GTPase activity
GO:0042098 T cell proliferation
GO:0042110 T cell activation
GO:0044351 macropinocytosis
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0046631 alpha-beta T cell activation
GO:0046633 alpha-beta T cell proliferation
GO:0050766 positive regulation of phagocytosis
Cellular Component
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000134516
View Gene Order
ENSMUSG00000020143
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
NetPath_24
TSLP pathway
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_11068
Nef and signal transduction pathway
REACT_6185
HIV Infection pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04062
Chemokine signaling pathway pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04062
Chemokine signaling pathway pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
Integrin signaling pathway pathway
PID NCI
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
rac1_reg_pathway
Regulation of RAC1 activity
Cross-References
SwissProt
TrEMBL F1N3K0
UniProt Splice Variant
Entrez Gene
UniGene Bt.112146 Bt.112207
RefSeq
HUGO HGNC:2988
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02049837 DAAA02049838 DAAA02049839 DAAA02049840 DAAA02049841 DAAA02049842 DAAA02049843 DAAA02049844 DAAA02049845 DAAA02049846 DAAA02049847 DAAA02049848
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca