InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ADORA1

Summary

InnateDB Protein

IDBP-679940.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADORA1

Protein Name

Adenosine receptor A1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015230

InnateDB Gene

IDBG-628574 (ADORA1)

Protein Structure

UniProt Annotation

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001609	G-protein coupled adenosine receptor activity
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding

Biological Process

GO:0001973	adenosine receptor signaling pathway
GO:0002686	negative regulation of leukocyte migration
GO:0003093	regulation of glomerular filtration
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0050728	negative regulation of inflammatory response
GO:0051930	regulation of sensory perception of pain
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0070256	negative regulation of mucus secretion

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001068 Adenosine A1 receptor
IPR001634 Adenosine receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00552
PR00424

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P28190