InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ADORA1

Summary

InnateDB Gene

IDBG-628574.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADORA1

Gene Name

Adenosine receptor A1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011461

Encoded Proteins

IDBP-679940

Adenosine receptor A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163485:
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5\' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:718146-759737

Strand

Forward strand

Band

Transcripts

ENSBTAT00000015230

ENSBTAP00000015230

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001609	G-protein coupled adenosine receptor activity
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding

Biological Process

GO:0001973	adenosine receptor signaling pathway
GO:0002686	negative regulation of leukocyte migration
GO:0003093	regulation of glomerular filtration
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0050728	negative regulation of inflammatory response
GO:0051930	regulation of sensory perception of pain
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0070256	negative regulation of mucus secretion