Version 5.4
Bos taurus Protein: CARTPT
Summary
InnateDB Protein IDBP-679969.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARTPT
Protein Name Cocaine- and amphetamine-regulated transcript proteinCART(1-39)CART(42-89)
Synonyms CART;
Species Bos taurus
Ensembl Protein ENSBTAP00000055162
InnateDB Gene IDBG-628603 (CARTPT)
Protein Structure
UniProt Annotation
Function Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000186 activation of MAPKK activity
GO:0001678 cellular glucose homeostasis
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007268 synaptic transmission
GO:0008343 adult feeding behavior
GO:0009267 cellular response to starvation
GO:0032099 negative regulation of appetite
GO:0032812 positive regulation of epinephrine secretion
GO:0032922 circadian regulation of gene expression
GO:0045777 positive regulation of blood pressure
GO:0045779 negative regulation of bone resorption
GO:0046850 regulation of bone remodeling
GO:0051971 positive regulation of transmission of nerve impulse
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0030141 secretory granule
Protein Structure and Domains
PDB ID
InterPro IPR009106 CART satiety factor
PFAM PF06373
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q68RJ9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 493726
UniGene Bt.20015
RefSeq NP_001007821
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY603972 BC114792
GenPept AAI14793 AAT99018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca