Version 5.4
Bos taurus Protein: IL34
Summary
InnateDB Protein IDBP-680163.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL34
Protein Name Interleukin-34
Synonyms C18H16ORF77; IL-34;
Species Bos taurus
Ensembl Protein ENSBTAP00000046513
InnateDB Gene IDBG-628785 (IL34)
Protein Structure
UniProt Annotation
Function Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250UniProtKB:Q6ZMJ4}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005157 macrophage colony-stimulating factor receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002376 immune system process
GO:0006954 inflammatory response
GO:0008284 positive regulation of cell proliferation
GO:0045087 innate immune response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR020415 Interleukin-34
PFAM PF15036
PRINTS PR01938
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6QL48
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508292
UniGene Bt.53591
RefSeq NP_001093794
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146187
GenPept AAI46188

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca