InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CYP51A1

Summary

InnateDB Protein

IDBP-680361.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP51A1

Protein Name

Lanosterol 14-alpha demethylase

Synonyms

CYP51;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002582

InnateDB Gene

IDBG-628968 (CYP51A1)

Protein Structure

UniProt Annotation

Function

Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}. Microsome membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008398	sterol 14-demethylase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006694	steroid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0008202	steroid metabolic process
GO:0008203	cholesterol metabolic process
GO:0016126	sterol biosynthetic process
GO:0055114	oxidation-reduction process
GO:0070988	demethylation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031090	organelle membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV

PFAM

PF00067

PRINTS

PR00385
PR00359
PR00463
PR00465

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q4PJW3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

505060

UniGene

Bt.64534

RefSeq

NP_001020490

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC149346 DQ078267 DQ085625

GenPept

AAI49347 AAY82452 AAZ74630