InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CYP51A1

Summary

InnateDB Gene

IDBG-628968.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP51A1

Gene Name

Lanosterol 14-alpha demethylase

Synonyms

CYP51

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001992

Encoded Proteins

IDBP-680361

Lanosterol 14-alpha demethylase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000001630:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:9306414-9323252

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002582

ENSBTAP00000002582

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008398	sterol 14-demethylase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006694	steroid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0008202	steroid metabolic process
GO:0008203	cholesterol metabolic process
GO:0016126	sterol biosynthetic process
GO:0055114	oxidation-reduction process
GO:0070988	demethylation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031090	organelle membrane
GO:0043231	intracellular membrane-bounded organelle