InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ESD

Summary

InnateDB Protein

IDBP-680425.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ESD

Protein Name

S-formylglutathione hydrolase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004431

InnateDB Gene

IDBG-629030 (ESD)

Protein Structure

UniProt Annotation

Function

Serine hydrolase involved in the detoxification of formaldehyde. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasmic vesicle {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity
GO:0016788	hydrolase activity, acting on ester bonds
GO:0018738	S-formylglutathione hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0046294	formaldehyde catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0031410	cytoplasmic vesicle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000801 Putative esterase
IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR008391 Acetyl xylan esterase
IPR014186 S-formylglutathione hydrolase
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00756
PF00326
PF05448

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08E20

PhosphoSite