Version 5.4
Bos taurus Protein: STAR
Summary
InnateDB Protein IDBP-680559.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAR
Protein Name Steroidogenic acute regulatory protein, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000044633
InnateDB Gene IDBG-629166 (STAR)
Protein Structure
UniProt Annotation
Function Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion.
Disease Associations
Tissue Specificity Corpus luteum and adrenal gland.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
GO:0015485 cholesterol binding
GO:0017127 cholesterol transporter activity
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006810 transport
GO:0006869 lipid transport
GO:0008203 cholesterol metabolic process
GO:0008211 glucocorticoid metabolic process
GO:0030301 cholesterol transport
GO:0044255 cellular lipid metabolic process
GO:0050810 regulation of steroid biosynthetic process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR000799 Steroidogenic acute regulatory protein, animal
IPR002913 START domain
PFAM PF01852
PRINTS PR00978
PIRSF
SMART SM00234
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q28918
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281507
UniGene Bt.88272
RefSeq NP_776614
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC110213 Y17259 Y17260
GenPept AAI10214 CAA76717 CAA76718

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca