Version 5.4
Bos taurus Gene: STAR
Summary
InnateDB Gene IDBG-629166.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAR
Gene Name Steroidogenic acute regulatory protein, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000033345
Encoded Proteins
IDBP-680559
Steroidogenic acute regulatory protein, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147465:
The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 27:33016930-33024353
Strand Reverse strand
Band
Transcripts
ENSBTAT00000047426 ENSBTAP00000044633
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
GO:0015485 cholesterol binding
GO:0017127 cholesterol transporter activity
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006810 transport
GO:0006869 lipid transport
GO:0008203 cholesterol metabolic process
GO:0008211 glucocorticoid metabolic process
GO:0030301 cholesterol transport
GO:0044255 cellular lipid metabolic process
GO:0050810 regulation of steroid biosynthetic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000147465
View Gene Order
ENSMUSG00000031574
View Gene Order
Pathways
NETPATH
REACTOME
REACT_211020
Pregnenolone biosynthesis pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_208375
Metabolism of steroid hormones and vitamin D pathway
REACT_219139
Metabolism pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11038
Pregnenolone biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_223561
Pregnenolone biosynthesis pathway
REACT_220061
Metabolism of steroid hormones and vitamin D pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.106718 Bt.87242 Bt.88272
RefSeq NM_174189
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca