Version 5.4
Bos taurus Protein: TRPC6
Summary
InnateDB Protein IDBP-680632.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRPC6
Protein Name Short transient receptor potential channel 6
Synonyms trp6;
Species Bos taurus
Ensembl Protein ENSBTAP00000053428
InnateDB Gene IDBG-629235 (TRPC6)
Protein Structure
UniProt Annotation
Function Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (By similarity). Seems not to be activated by intracellular calcium store depletion (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005488 binding
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0032414 positive regulation of ion transmembrane transporter activity
GO:0051928 positive regulation of calcium ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0036057 slit diaphragm
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR002153 Transient receptor potential channel, canonical
IPR004729 Transient receptor potential channel
IPR005462 Transient receptor potential channel, canonical 6
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR013555 Transient receptor ion channel domain
IPR016024 Armadillo-type fold
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF00520
PF08016
PF08344
PF11929
PF12796
PRINTS PR01415
PR01097
PR01647
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9MYW0
PhosphoSite PhosphoSite-
TrEMBL Q6L6S2
UniProt Splice Variant
Entrez Gene 407151
UniGene
RefSeq NP_001160044
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB179746 AJ271069 DAAA02039924 DAAA02039925
GenPept BAD19016 CAC01677

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca