Bos taurus Protein: FBXO8
Summary
InnateDB Protein IDBP-680731.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO8
Protein Name F-box only protein 8
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008831
InnateDB Gene IDBG-629323 (FBXO8)
Protein Structure
UniProt Annotation
Function May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential). {ECO:0000305}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0030036 actin cytoskeleton organization
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR000904 Sec7 domain
IPR001810 F-box domain
PFAM PF01369
PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00222
SM00256
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E9G6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 538528
UniGene Bt.37057
RefSeq NP_001015667
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103444 BT020782 BT020954
GenPept AAI03445 AAX08799 AAX08971