InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LPO

Summary

InnateDB Protein

IDBP-680785.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPO

Protein Name

Lactoperoxidase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000016986

InnateDB Gene

IDBG-629359 (LPO)

Protein Structure

UniProt Annotation

Function

LPO is an antimicrobial agent; it utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). LPO is thought to help protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Mammary gland; milk.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005509	calcium ion binding
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0036393	thiocyanate peroxidase activity
GO:0046872	metal ion binding

Biological Process

GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
GO:0006979	response to oxidative stress
GO:0018969	thiocyanate metabolic process
GO:0019731	antibacterial humoral response
GO:0042742	defense response to bacterium
GO:0042744	hydrogen peroxide catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome