Version 5.4
Bos taurus Protein: C1GALT1
Summary
InnateDB Protein IDBP-680843.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1GALT1
Protein Name Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000006571
InnateDB Gene IDBG-629436 (C1GALT1)
Protein Structure
UniProt Annotation
Function Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008378 galactosyltransferase activity
GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001822 kidney development
GO:0006486 protein glycosylation
GO:0007275 multicellular organismal development
GO:0016266 O-glycan processing
GO:0030154 cell differentiation
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002659 Glycosyl transferase, family 31
IPR003378 Fringe-like
PFAM PF01762
PF02434
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VC84
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 539417
UniGene Bt.22740
RefSeq NP_001069628
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120299
GenPept AAI20300

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca