Version 5.4
Bos taurus Protein: VPS26A
Summary
InnateDB Protein IDBP-680864.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS26A
Protein Name Vacuolar protein sorting-associated protein 26A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000022455
InnateDB Gene IDBG-629460 (VPS26A)
Protein Structure
UniProt Annotation
Function Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0015031 protein transport
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0031982 vesicle
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR028934 Vacuolar protein sorting protein 26 related
PFAM PF03643
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VD53
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 510574
UniGene Bt.5737
RefSeq NP_001068923
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC119831 BT030523
GenPept AAI19832 ABQ12963

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca