InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: VPS26A

Summary

InnateDB Gene

IDBG-629460.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS26A

Gene Name

Vacuolar protein sorting-associated protein 26A

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016882

Encoded Proteins

IDBP-680864

Vacuolar protein sorting-associated protein 26A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122958:
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:25683639-25708826

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022455

ENSBTAP00000022455

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0015031	protein transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0031982	vesicle
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome