Version 5.4
Bos taurus Protein: FES
Summary
InnateDB Protein IDBP-680876.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FES
Protein Name tyrosine-protein kinase Fes/Fps
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003828
InnateDB Gene IDBG-629472 (FES)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0034987 immunoglobulin receptor binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006468 protein phosphorylation
GO:0008360 regulation of cell shape
GO:0010976 positive regulation of neuron projection development
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030155 regulation of cell adhesion
GO:0031116 positive regulation of microtubule polymerization
GO:0042127 regulation of cell proliferation
GO:0043304 regulation of mast cell degranulation
GO:0045595 regulation of cell differentiation
GO:0045639 positive regulation of myeloid cell differentiation
GO:0046777 protein autophosphorylation
GO:2000145 regulation of cell motility
GO:2000251 positive regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0015630 microtubule cytoskeleton
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001060 FCH domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016250 Tyrosine-protein kinase, Fes/Fps type
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF00017
PF14633
PF00611
PF07714
PRINTS PR00401
PR00109
PIRSF PIRSF000632
SMART SM00252
SM00055
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5E9H3
UniProt Splice Variant
Entrez Gene 507304
UniGene Bt.53298
RefSeq NP_001027471
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT020947 DAAA02052164 DAAA02052165 DAAA02052166
GenPept AAX08964

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca