InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PACSIN1

Summary

InnateDB Protein

IDBP-680905.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PACSIN1

Protein Name

Protein kinase C and casein kinase substrate in neurons protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021459

InnateDB Gene

IDBG-629496 (PACSIN1)

Protein Structure

UniProt Annotation

Function

Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell projection {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites. Associates with membranes via its F-BAR domain (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008092	cytoskeletal protein binding
GO:0008289	lipid binding

Biological Process

GO:0006897	endocytosis
GO:0007015	actin filament organization
GO:0045806	negative regulation of endocytosis
GO:0048488	synaptic vesicle endocytosis
GO:0048666	neuron development
GO:0048812	neuron projection morphogenesis
GO:0072657	protein localization to membrane
GO:0097320	membrane tubulation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0030137	COPI-coated vesicle
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0032587	ruffle membrane
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0043679	axon terminus
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR001060 FCH domain
IPR001452 SH3 domain
IPR011511 Variant SH3 domain

PFAM

PF00611
PF00018
PF14604
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00055
SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A7MBI0

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

520488

UniGene

Bt.35936

RefSeq

NP_001094571

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC151572 BC153241

GenPept

AAI51573 AAI53242