Version 5.4
Bos taurus Protein: IL15
Summary
InnateDB Protein IDBP-680991.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL15
Protein Name Interleukin-15
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024226
InnateDB Gene IDBG-629577 (IL15)
Protein Structure
UniProt Annotation
Function Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005515 protein binding
Biological Process
GO:0001779 natural killer cell differentiation
GO:0001866 NK T cell proliferation
GO:0006955 immune response
GO:0032740 positive regulation of interleukin-17 production
GO:0032819 positive regulation of natural killer cell proliferation
GO:0032825 positive regulation of natural killer cell differentiation
GO:0042102 positive regulation of T cell proliferation
GO:0045062 extrathymic T cell selection
GO:0045580 regulation of T cell differentiation
GO:0048469 cell maturation
GO:0048535 lymph node development
GO:0050691 regulation of defense response to virus by host
GO:0050778 positive regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003443 Interleukin-15/Interleukin-21 family
IPR020439 Interleukin-15
IPR020466 Interleukin-15, mammal
PFAM PF02372
PRINTS PR01930
PR01947
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q28028
PhosphoSite PhosphoSite-
TrEMBL B3GDZ2
UniProt Splice Variant
Entrez Gene 281248
UniGene
RefSeq NP_776515
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL EU682380 U42433
GenPept AAA85130 ACD81651

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca