InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IL15

Summary

InnateDB Gene

IDBG-629577.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL15

Gene Name

Interleukin-15

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018200

Encoded Proteins

IDBP-680991

Interleukin-15

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20026737

[Homo sapiens] IL15 is a pluripotent anti-apoptotic cytokine that signals to cells of both the innate and adaptive immune system and is regarded as a highly promising immunomodulatory agent in cancer therapy. IL15 prevents two immunopathologic hallmarks of sepsis, namely, apoptosis and immunosuppression, and improves survival in two different models of sepsis.

PMID 22084435

[Homo sapiens] IL15 regulates homeostasis and terminal maturation of NKT cells. (Demonstrated in mice)

PMID 22940097

[Homo sapiens] IL15 secreted by inflammatory monocytes is critical for the differentiation of memory CD8(+) T and NK lymphocytes into antimicrobial effector cells. (Demonstrated in mice)

PMID 22084435

[Mus musculus] Il15 regulates homeostasis and terminal maturation of NKT cells.

PMID 22940097

[Mus musculus] IL15 secreted by inflammatory monocytes is critical for the differentiation of memory CD8(+) T and NK lymphocytes into antimicrobial effector cells.

PMID 25466888

[Mus musculus] Cxcr3 expression in innate CD8+ T cells defines protective antibacterial and cancer immunity upon Il15 stimulation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164136:
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other\'s activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:16347925-16363886

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000024226

ENSBTAP00000024226

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005515	protein binding

Biological Process

GO:0001779	natural killer cell differentiation
GO:0001866	NK T cell proliferation
GO:0006955	immune response
GO:0032740	positive regulation of interleukin-17 production
GO:0032819	positive regulation of natural killer cell proliferation
GO:0032825	positive regulation of natural killer cell differentiation
GO:0042102	positive regulation of T cell proliferation
GO:0045062	extrathymic T cell selection
GO:0045580	regulation of T cell differentiation
GO:0048469	cell maturation
GO:0048535	lymph node development
GO:0050691	regulation of defense response to virus by host
GO:0050778	positive regulation of immune response