InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PLCG2

Summary

InnateDB Protein

IDBP-681037.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCG2

Protein Name

phospholipase C, gamma 2 (phosphatidylinositol-specific)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002717

InnateDB Gene

IDBG-629513 (PLCG2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity

Biological Process

GO:0002316	follicular B cell differentiation
GO:0006629	lipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0007165	signal transduction
GO:0009395	phospholipid catabolic process
GO:0010468	regulation of gene expression
GO:0016042	lipid catabolic process
GO:0030183	B cell differentiation
GO:0032237	activation of store-operated calcium channel activity
GO:0032496	response to lipopolysaccharide
GO:0032959	inositol trisphosphate biosynthetic process
GO:0035556	intracellular signal transduction
GO:0043069	negative regulation of programmed cell death
GO:0050852	T cell receptor signaling pathway
GO:0050853	B cell receptor signaling pathway
GO:0051209	release of sequestered calcium ion into cytosol

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR000980 SH2 domain
IPR001192 Phosphoinositide phospholipase C family
IPR001452 SH3 domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR011511 Variant SH3 domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM