InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ITSN1

Summary

InnateDB Protein

IDBP-681062.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITSN1

Protein Name

intersectin 1 (SH3 domain protein)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000029333

InnateDB Gene

IDBG-629463 (ITSN1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 109 interaction(s) predicted by orthology.

Predicted by orthology
Total	109 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019209	kinase activator activity
GO:0032947	protein complex scaffold
GO:0070064	proline-rich region binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0042327	positive regulation of phosphorylation
GO:0043524	negative regulation of neuron apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0030027	lamellipodium
GO:0030139	endocytic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000219 Dbl homology (DH) domain
IPR000261 EPS15 homology (EH)
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR002048 EF-hand domain
IPR011511 Variant SH3 domain

PFAM