InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ITSN1

Summary

InnateDB Gene

IDBG-629463.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITSN1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021997

Encoded Proteins

IDBP-681062

intersectin 1 (SH3 domain protein)

IDBP-681075

intersectin 1 (SH3 domain protein)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000205726:
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:944294-1188287

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000029333	ENSBTAP00000029333
ENSBTAT00000065213	ENSBTAP00000055481

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 109 interaction(s) predicted by orthology.

Predicted by orthology
Total	109 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019209	kinase activator activity
GO:0032947	protein complex scaffold
GO:0070064	proline-rich region binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0042327	positive regulation of phosphorylation
GO:0043524	negative regulation of neuron apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0051897	positive regulation of protein kinase B signaling