Version 5.4
| Bos taurus Protein: TRPC4 | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-681248.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | TRPC4 | ||||||||||
| Protein Name | Short transient receptor potential channel 4 | ||||||||||
| Synonyms | |||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Protein | ENSBTAP00000055610 | ||||||||||
| InnateDB Gene | IDBG-629819 (TRPC4) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Acts as a cell-cell contact-dependent endothelial calcium entry channel (By similarity). {ECO:0000250}. | ||||||||||
| Subcellular Localization | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | Expressed in adrenal gland. Lower expression in heart and retina. Also expressed in testis. The short isoform is specifically expressed in the adrenal gland. | ||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | |||||||||||
| InterPro |
IPR002153
Transient receptor potential channel, canonical IPR005460 Transient receptor potential channel, canonical 4 IPR005821 Ion transport domain |
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| PFAM |
PF00520
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| PRINTS |
PR01097
PR01645 |
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| PIRSF | |||||||||||
| SMART | |||||||||||
| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | P79100 | ||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 282102 | ||||||||||
| UniGene | Bt.4556 | ||||||||||
| RefSeq | |||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AJ224862 X99792 | ||||||||||
| GenPept | CAA12161 CAA68125 | ||||||||||