Version 5.4
| Bos taurus Protein: PSAP | |||||||||||||||||
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| Summary | |||||||||||||||||
| InnateDB Protein | IDBP-681347.3 | ||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
| Gene Symbol | PSAP | ||||||||||||||||
| Protein Name | proactivator polypeptide | ||||||||||||||||
| Synonyms | |||||||||||||||||
| Species | Bos taurus | ||||||||||||||||
| Ensembl Protein | ENSBTAP00000044260 | ||||||||||||||||
| InnateDB Gene | IDBG-629915 (PSAP) | ||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||
| Function | Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.Saposin-B stimulates the hydrolysis of galacto- cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases (By similarity). {ECO:0000250}.Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). {ECO:0000250}.Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. {ECO:0000250}.Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. {ECO:0000250}. | ||||||||||||||||
| Subcellular Localization | Lysosome.Prosaposin: Secreted. Note=Secreted as a fully glycosylated 70 kDa protein composed of complex glycans. {ECO:0000250}. | ||||||||||||||||
| Disease Associations | |||||||||||||||||
| Tissue Specificity | |||||||||||||||||
| Comments | |||||||||||||||||
| Interactions | |||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||
| PDB ID | |||||||||||||||||
| InterPro |
IPR003119
Saposin type A IPR007856 Saposin-like type B, 1 IPR008138 Saposin-like type B, 2 IPR008139 Saposin B IPR008373 Saposin IPR011001 Saposin-like IPR021165 Saposin, chordata |
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| PFAM |
PF02199
PF05184 PF03489 |
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| PRINTS |
PR01797
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| PIRSF |
PIRSF002431
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| SMART |
SM00162
SM00741 |
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| TIGRFAMs | |||||||||||||||||
| Post-translational Modifications | |||||||||||||||||
| Modification | |||||||||||||||||
| Cross-References | |||||||||||||||||
| SwissProt | P26779 | ||||||||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||||||||
| TrEMBL | |||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||
| Entrez Gene | 281433 | ||||||||||||||||
| UniGene | Bt.42764 | ||||||||||||||||
| RefSeq | |||||||||||||||||
| HUGO | |||||||||||||||||
| OMIM | |||||||||||||||||
| CCDS | |||||||||||||||||
| HPRD | |||||||||||||||||
| IMGT | |||||||||||||||||
| EMBL | AB036791 BC105409 | ||||||||||||||||
| GenPept | AAI05410 BAA95677 | ||||||||||||||||