InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PSAP

Summary

InnateDB Gene

IDBG-629915.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSAP

Gene Name

Proactivator polypeptide Saposin-A Saposin-B Saposin-C Saposin-D

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021499

Encoded Proteins

IDBP-681347

proactivator polypeptide

IDBP-681349

proactivator polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197746:
This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:28123710-28157099

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000047021	ENSBTAP00000044260
ENSBTAT00000028655	ENSBTAP00000028655

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006665	sphingolipid metabolic process
GO:0019216	regulation of lipid metabolic process
GO:0043408	regulation of MAPK cascade
GO:0048589	developmental growth
GO:0060736	prostate gland growth
GO:0060742	epithelial cell differentiation involved in prostate gland development
GO:0071310	cellular response to organic substance