InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MICU1

Summary

InnateDB Protein

IDBP-681403.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MICU1

Protein Name

Calcium uptake protein 1, mitochondrial

Synonyms

CBARA1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000007636

InnateDB Gene

IDBG-629968 (MICU1)

Protein Structure

UniProt Annotation

Function

Key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU1 acts as a stimulator of MCU that senses calcium level via its EF-hand domains: enhances MCU opening at high Ca(2+) concentration, allowing a rapid response of mitochondria to Ca(2+) signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}. Note=Localizes at the outer surface of the mitochondrion inner membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006851	mitochondrial calcium ion transport
GO:0036444	calcium ion import into mitochondrion
GO:0051260	protein homooligomerization
GO:0051560	mitochondrial calcium ion homeostasis
GO:0051561	positive regulation of mitochondrial calcium ion concentration
GO:0070509	calcium ion import

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0016020	membrane
GO:0032592	integral component of mitochondrial membrane
GO:0034704	calcium channel complex
GO:1990246	uniplex complex

Protein Structure and Domains

PDB ID

InterPro

IPR002048 EF-hand domain

PFAM

PF00036
PF13202
PF13405

PRINTS

PIRSF

SMART

SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0IIL1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

507899

UniGene

Bt.10107

RefSeq

NP_001068806

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC122590

GenPept

AAI22591