InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SOD1

Summary

InnateDB Protein

IDBP-681496.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOD1

Protein Name

Superoxide dismutase

Synonyms

SOD1L1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000032384

InnateDB Gene

IDBG-630058 (SOD1)

Protein Structure

UniProt Annotation

Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Subcellular Localization

Cytoplasm. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004784	superoxide dismutase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0030346	protein phosphatase 2B binding
GO:0046872	metal ion binding
GO:0051087	chaperone binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0000209	protein polyubiquitination
GO:0000303	response to superoxide
GO:0001541	ovarian follicle development
GO:0001817	regulation of cytokine production
GO:0001819	positive regulation of cytokine production
GO:0001895	retina homeostasis
GO:0002262	myeloid cell homeostasis
GO:0006302	double-strand break repair
GO:0006309	apoptotic DNA fragmentation
GO:0006749	glutathione metabolic process
GO:0006801	superoxide metabolic process
GO:0006879	cellular iron ion homeostasis
GO:0007283	spermatogenesis
GO:0007566	embryo implantation
GO:0007569	cell aging
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0008217	regulation of blood pressure
GO:0009408	response to heat
GO:0010033	response to organic substance
GO:0019226	transmission of nerve impulse
GO:0019430	removal of superoxide radicals
GO:0032287	peripheral nervous system myelin maintenance
GO:0040014	regulation of multicellular organism growth
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043085	positive regulation of catalytic activity
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0044419	interspecies interaction between organisms
GO:0045471	response to ethanol
GO:0045541	negative regulation of cholesterol biosynthetic process
GO:0045859	regulation of protein kinase activity
GO:0046716	muscle cell cellular homeostasis
GO:0048678	response to axon injury
GO:0050665	hydrogen peroxide biosynthetic process
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0051881	regulation of mitochondrial membrane potential
GO:0055114	oxidation-reduction process
GO:0060047	heart contraction
GO:0060052	neurofilament cytoskeleton organization
GO:0060087	relaxation of vascular smooth muscle
GO:0060088	auditory receptor cell stereocilium organization
GO:0072593	reactive oxygen species metabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031012	extracellular matrix
GO:0031410	cytoplasmic vesicle
GO:0032839	dendrite cytoplasm
GO:0043025	neuronal cell body
GO:0043234	protein complex