Version 5.4
Bos taurus Protein: HMGN3
Summary
InnateDB Protein IDBP-681497.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGN3
Protein Name High mobility group nucleosome-binding domain-containing protein 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000045886
InnateDB Gene IDBG-630059 (HMGN3)
Protein Structure
UniProt Annotation
Function Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at similar levels in mature oocytes and 2-4 cell embryos, but at higher levels in 8-16 cell embryos, morulae and blastocysts. {ECO:0000269PubMed:19393058}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016568 chromatin modification
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000079 High mobility group nucleosome-binding domain-containing family
PFAM PF01101
PRINTS PR00925
PIRSF
SMART SM00527
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZBV4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 515652
UniGene Bt.10138
RefSeq NP_001029676
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103089
GenPept AAI03090

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca