Version 5.4
Bos taurus Gene: HMGN3
Summary
InnateDB Gene IDBG-630059.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGN3
Gene Name High mobility group nucleosome-binding domain-containing protein 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001422
Encoded Proteins
IDBP-681497
High mobility group nucleosome-binding domain-containing protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118418:
Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:19000364-19035860
Strand Reverse strand
Band
Transcripts
ENSBTAT00000048930 ENSBTAP00000045886
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016568 chromatin modification
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000118418
View Gene Order
ENSMUSG00000066456
View Gene Order
Cross-References
SwissProt Q3ZBV4
TrEMBL
UniProt Splice Variant
Entrez Gene 515652
UniGene Bt.10138
RefSeq NM_001034504 XM_005210687
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103089
GenPept AAI03090
RNA Seq Atlas 515652

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca