InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RASGRF1

Summary

InnateDB Protein

IDBP-681631.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASGRF1

Protein Name

Ras protein-specific guanine nucleotide-releasing factor 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026564

InnateDB Gene

IDBG-630181 (RASGRF1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0035254	glutamate receptor binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0008283	cell proliferation
GO:0031175	neuron projection development
GO:0032320	positive regulation of Ras GTPase activity
GO:0032863	activation of Rac GTPase activity
GO:0035020	regulation of Rac protein signal transduction
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0046578	regulation of Ras protein signal transduction
GO:0048168	regulation of neuronal synaptic plasticity
GO:0051056	regulation of small GTPase mediated signal transduction
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0030426	growth cone

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000219 Dbl homology (DH) domain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001849 Pleckstrin homology domain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR023578 Ras guanine nucleotide exchange factor domain

PFAM

PF00612
PF00621
PF00618
PF00169
PF00617

PRINTS

PIRSF

SMART

SM00015
SM00325
SM00229
SM00233
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite