InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RASGRF1

Summary

InnateDB Gene

IDBG-630181.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASGRF1

Gene Name

ras-specific guanine nucleotide-releasing factor 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019940

Encoded Proteins

IDBP-681631

Ras protein-specific guanine nucleotide-releasing factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000058335:
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:25714965-25816371

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000026564

ENSBTAP00000026564

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0035254	glutamate receptor binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0008283	cell proliferation
GO:0031175	neuron projection development
GO:0032320	positive regulation of Ras GTPase activity
GO:0032863	activation of Rac GTPase activity
GO:0035020	regulation of Rac protein signal transduction
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0046578	regulation of Ras protein signal transduction
GO:0048168	regulation of neuronal synaptic plasticity
GO:0051056	regulation of small GTPase mediated signal transduction
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity