InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: THPO

Summary

InnateDB Protein

IDBP-68173.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THPO

Protein Name

thrombopoietin

Synonyms

MGDF; MKCSF; ML; MPLLG; THCYT1; TPO;

Species

Homo sapiens

Ensembl Protein

ENSP00000204615

InnateDB Gene

IDBG-68171 (THPO)

Protein Structure

UniProt Annotation

Function

Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

Subcellular Localization

Secreted.

Disease Associations

Thrombocythemia 1 (THCYT1) [MIM:187950]: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005179	hormone activity
GO:0008083	growth factor activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0007275	multicellular organismal development
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0030099	myeloid cell differentiation
GO:0030168	platelet activation
GO:0038163	thrombopoietin-mediated signaling pathway
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0051897	positive regulation of protein kinase B signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade