Version 5.4
Homo sapiens Gene: THPO
Summary
InnateDB Gene IDBG-68171.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THPO
Gene Name thrombopoietin
Synonyms MGDF; MKCSF; ML; MPLLG; THCYT1; TPO
Species Homo sapiens
Ensembl Gene ENSG00000090534
Encoded Proteins
IDBP-68173
thrombopoietin
IDBP-386170
thrombopoietin
IDBP-386173
thrombopoietin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternate splicing results in multiple transcript variants of this gene.[provided by RefSeq, Jun 2012]
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5\' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:184371935-184378144
Strand Reverse strand
Band q27.1
Transcripts
ENST00000204615 ENSP00000204615
ENST00000421442 ENSP00000411704
ENST00000445696 ENSP00000410763
ENST00000477594
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005179 hormone activity
GO:0008083 growth factor activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0007275 multicellular organismal development
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0030099 myeloid cell differentiation
GO:0030168 platelet activation
GO:0038163 thrombopoietin-mediated signaling pathway
GO:0045654 positive regulation of megakaryocyte differentiation
GO:0051897 positive regulation of protein kinase B signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022847
View Gene Order
ENSBTAG00000000476
Not yet available
Pathways
NETPATH
REACTOME
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
TPO signaling pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P40225
TrEMBL
UniProt Splice Variant
Entrez Gene 7066
UniGene Hs.1166 Hs.734657
RefSeq NM_001177597 NM_001177598 NM_000460 NM_001289997 NM_001289998 NM_001290003 NM_001290022 NM_001290026 NM_001290027 NM_001290028 XM_005247737 XM_006713738 XM_006713739
HUGO HGNC:11795
OMIM 600044
CCDS CCDS54693 CCDS3265
HPRD 02500
IMGT
EMBL BC130322 BC136338 BC143982 D32046 D32047 L33410 L36051 L36052 S76771 U11025 U17071 U59493 U59494 U59495
GenPept AAA50553 AAA59857 AAA74083 AAB03392 AAB03393 AAB03394 AAB33390 AAC37566 AAC37568 AAI30323 AAI36339 AAI43983 BAA06807 BAA21930
RNA Seq Atlas 7066

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca