InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RNF146B

Summary

InnateDB Protein

IDBP-681867.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF146B

Protein Name

E3 ubiquitin-protein ligase RNF146-B

Synonyms

RNF146;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000037915

InnateDB Gene

IDBG-630414 (RNF146B)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP- ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding
GO:0072572	poly-ADP-D-ribose binding

Biological Process

GO:0016055	Wnt signaling pathway
GO:0016567	protein ubiquitination
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051865	protein autoubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001841 Zinc finger, RING-type
IPR004170 WWE domain
IPR018123 WWE domain, subgroup

PFAM

PF13639
PF14634
PF02825

PRINTS

PIRSF

SMART

SM00184
SM00678

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3T139

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

788183

UniGene

Bt.88162

RefSeq

NP_001070448

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102139

GenPept

AAI02140