Version 5.4
Bos taurus Gene: RNF146B
Summary
InnateDB Gene IDBG-630414.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF146B
Gene Name E3 ubiquitin-protein ligase RNF146-B
Synonyms RNF146
Species Bos taurus
Ensembl Gene ENSBTAG00000034531
Encoded Proteins
IDBP-681867
E3 ubiquitin-protein ligase RNF146-B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118518:
Gene Information
Type Protein coding
Genomic Location Chromosome 9:24273357-24300611
Strand Reverse strand
Band
Transcripts
ENSBTAT00000038099 ENSBTAP00000037915
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
GO:0072572 poly-ADP-D-ribose binding
Biological Process
GO:0016055 Wnt signaling pathway
GO:0016567 protein ubiquitination
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051865 protein autoubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000118518
View Gene Order
ENSMUSG00000038876
View Gene Order
Pathways
NETPATH
REACTOME
REACT_212636
Signaling by Wnt pathway
REACT_242703
Signaling by WNT in cancer pathway
REACT_217918
TCF dependent signaling in response to WNT pathway
REACT_234280
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_242720
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_214353
Signal Transduction pathway
REACT_208889
degradation of AXIN pathway
REACT_236591
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207087
Disease pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_200766
degradation of AXIN pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_219129
degradation of AXIN pathway
REACT_188257
Signal Transduction pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q3T139
TrEMBL
UniProt Splice Variant
Entrez Gene 788183
UniGene Bt.88162
RefSeq NM_001076980 XM_005194141 XM_005210700 XM_005213758
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102139
GenPept AAI02140
RNA Seq Atlas 767901 788183

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca