Version 5.4
Bos taurus Protein: CYBA
Summary
InnateDB Protein IDBP-681887.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYBA
Protein Name Cytochrome b-245 light chain
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000005080
InnateDB Gene IDBG-630434 (CYBA)
Protein Structure
UniProt Annotation
Function Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
Subcellular Localization Cell membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0016175 superoxide-generating NADPH oxidase activity
GO:0016491 oxidoreductase activity
GO:0017124 SH3 domain binding
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006801 superoxide metabolic process
GO:0006954 inflammatory response
GO:0017004 cytochrome complex assembly
GO:0042554 superoxide anion generation
GO:0045087 innate immune response
GO:0045730 respiratory burst
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043020 NADPH oxidase complex
Protein Structure and Domains
PDB ID
InterPro IPR007732 Cytochrome b558 alpha-subunit
PFAM PF05038
PRINTS
PIRSF PIRSF019635
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O46521
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281111
UniGene Bt.4140
RefSeq NP_776459
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF036096 BC142380
GenPept AAC27246 AAI42381

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca